Myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgery

Autor: Steven W.M. Olde Damink, Malcolm A. West, Mark R Edwards, John N. Primrose, Fredrick Gleadowe, Sander S. Rensen, Mohammed Abu Hilal, David P J van Dijk, Denny Z. H. Levett, Sandy Jack, Thomas Reeves, Michael P.W. Grocott
Přispěvatelé: Surgery, RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Heelkunde (9)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Sarcopenia
Myosteatosis
lcsh:Diseases of the musculoskeletal system
Physical fitness
MUSCLE RADIATION ATTENUATION
Body composition
NEOADJUVANT CHEMOTHERAPY
0302 clinical medicine
Medicine
Orthopedics and Sports Medicine
Prospective Studies
Prospective cohort study
2. Zero hunger
Gastroenterology
lcsh:Human anatomy
Biliary Tract Surgical Procedures
PREOPERATIVE RISK-ASSESSMENT
030220 oncology & carcinogenesis
Cardiology
SKELETAL-MUSCLE
030211 gastroenterology & hepatology
Median body
Original Article
Female
Anaerobic exercise
medicine.medical_specialty
BODY-COMPOSITION
VISCERAL ADIPOSITY
lcsh:QM1-695
Pancreaticoduodenectomy
03 medical and health sciences
Muscular Diseases
Physiology (medical)
Internal medicine
Aerobic exercise
Hepatectomy
Humans
In patient
SARCOPENIC OBESITY
Sarcopenic obesity
ONCOLOGIC OUTCOMES
Aged
Hepatology
business.industry
LENGTH-OF-STAY
Perioperative
Original Articles
medicine.disease
Cardiopulmonary exercise testing
Oxygen uptake
030104 developmental biology
Physical therapy
PROGNOSTIC-FACTOR
lcsh:RC925-935
business
Zdroj: Journal of Cachexia, Sarcopenia and Muscle
Journal of cachexia, sarcopenia and muscle 10(4), 860-871 (2019). doi:10.1002/jcsm.12433
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 4, Pp 860-871 (2019)
Journal of cachexia, sarcopenia and muscle, 10(4), 860-871. Wiley
ISSN: 2190-6009
2190-5991
Popis: Background Body composition assessment, measured using single-slice computed tomography (CT) image at L3 level, and aerobic physical fitness, objectively measured using cardiopulmonary exercise testing (CPET), are each independently used for perioperative risk assessment. Sarcopenia (i.e. low skeletal muscle mass), myosteatosis [i.e. low skeletal muscle radiation attenuation (SM-RA)], and impaired objectively measured aerobic fitness (reduced oxygen uptake) have been associated with poor post-operative outcomes and survival in various cancer types. However, the association between CT body composition and physical fitness has not been explored. In this study, we assessed the association of CT body composition with selected CPET variables in patients undergoing hepatobiliary and pancreatic surgery. Methods A pragmatic prospective cohort of 123 patients undergoing hepatobiliary and pancreatic surgery were recruited. All patients underwent preoperative CPET. Preoperative CT scans were analysed using a single-slice CT image at L3 level to assess skeletal muscle mass, adipose tissue mass, and muscle radiation attenuation. Multivariate linear regression was used to test the association between CPET variables and body composition. Main outcomes were oxygen uptake at anaerobic threshold (V?O-2 at AT), oxygen uptake at peak exercise (V?O-2 peak), skeletal muscle mass, and SM-RA. Results Of 123 patients recruited [77 men (63%), median age 66.9 +/- 11.7, median body mass index 27.3 +/- 5.2], 113 patients had good-quality abdominal CT scans available and were included. Of the CT body composition variables, SM-RA had the strongest correlation with V?O-2 peak (r = 0.57, P
Databáze: OpenAIRE
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