Nanoparticles with PDT and PTT synergistic properties working with dual NIR-light source simultaneously
| Autor: | Zeynep Deniz Şahin İnan, Mustafa Ergul, Merve Kucukoflaz, Fazli Sozmen |
|---|---|
| Přispěvatelé: | Tıp Fakültesi, Mühendislik Fakültesi |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Nir light General Chemical Engineering medicine.medical_treatment Cancer therapy Nanoparticle Photodynamic therapy Nanotechnology 02 engineering and technology General Chemistry Photothermal therapy 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Verteporfin 0104 chemical sciences medicine Treatment strategy 0210 nano-technology Laser light medicine.drug |
| Zdroj: | RSC Advances. 11:2383-2389 |
| ISSN: | 2046-2069 |
| Popis: | A non-toxic nano system using a cleverly designed dual light can be an important treatment strategy in cancer therapy. Here, we propose a unique concept of synergistic non-toxic nanoplatform, which operates with dual light. An apoferritin nano-platform whose surface was modified with Verteporfin (Visudyne (R)) and with ultra-small CuS nanoparticles in the center demonstrated the synergistic effect of photodynamic therapy (PDT) and photothermal therapy (PTT). The synergistic effect of PDT and PTT were achieved with 808 nm laser light and 690 nm LED light, respectively. These results not only give a new horizon to multifunctional nanostructures for biological applications but also show a new way to design the novel PDT and PTT agents. |
| Databáze: | OpenAIRE |
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