Erythropoietin and thrombopoietin mimetics: Natural alternatives to erythrocyte and platelet disorders
| Autor: | Usha Gutti, Ravinder Kandi, Ravi Kumar Gutti, Ram Babu Undi, Aneesh Kotipalli, Raja Gopal Venakata Saladi, Satya Ratan Pasupuleti, Itishri Sahu |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Blood transfusion Erythrocytes medicine.medical_treatment Platelet disorder Thrombopoietin mimetics Bioinformatics law.invention 03 medical and health sciences 0302 clinical medicine law Biomimetic Materials medicine Animals Humans Erythropoietin Thrombopoietin Blood Platelet Disorders business.industry food and beverages Hematology Recombinant Proteins Haematopoiesis 030104 developmental biology Oncology 030220 oncology & carcinogenesis Immunology Recombinant DNA business medicine.drug |
| Zdroj: | Critical reviews in oncology/hematology. 108 |
| ISSN: | 1879-0461 |
| Popis: | Erythropoietin (EPO) and thrombopoietin (TPO) plays a major role in the regulation of hematopoietic development. Though, blood transfusion was the most widely used method to treat low blood count, over the years with advancements in recombinant technology and drug designing, the EPO and TPO mimetics are dominating the therapeutics industry. On the other hand, the recombinant human EPO and TPO are associated either with reduced half-life or immune reactions. The restoration of alternate medicine in recent years has the hope to overcome limitations associated with recombinant technology, to treat various disorder including blood diseases, with low to no side effects. The work in recent years on plant derived mimetics suggests a paradigm shift in the way diseases are treated. Here, we are providing a comprehensive review on the EPO and TPO recombinant counterparts and synthetic mimetics studied till date with a focus on the need for more natural alternatives. |
| Databáze: | OpenAIRE |
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