Role of Restaging Transurethral Resection for T1 Non–muscle invasive Bladder Cancer: A Systematic Review and Meta-analysis
| Autor: | Angelo Naselli, Giorgio Guazzoni, Rodolfo Hurle, Alberto Saita, Massimo Lazzeri, Stefano Paparella, Giuliana Lista, Paolo Casale, Nicolò Maria Buffi, Giovanni Lughezzani |
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| Rok vydání: | 2018 |
| Předmět: |
Reoperation
Detrusor muscle medicine.medical_specialty Neoplasm Residual Urology Population 030232 urology & nephrology Context (language use) Cystectomy 03 medical and health sciences 0302 clinical medicine medicine Humans education Neoplasm Staging education.field_of_study Bladder cancer medicine.diagnostic_test business.industry Cystoscopy medicine.disease Confidence interval Surgery medicine.anatomical_structure Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Meta-analysis Population study business |
| Zdroj: | European Urology Focus. 4:558-567 |
| ISSN: | 2405-4569 |
| DOI: | 10.1016/j.euf.2016.12.011 |
| Popis: | Context Repeat transurethral resection (reTUR) is advocated as a fundamental step towards complete clearance and appropriate staging of T1 bladder cancer tumors. Objective To assess the impact of reTUR in T1 bladder cancer via a systematic review of the literature and meta-analysis of available data sets. Evidence acquisition After definition of the population and of the outcome, a systematic search of English language articles in the literature from 1980 to 2016 was performed. The pooled prevalence of residual tumor and of upstaging at reTUR were assessed and computed using a random effects model to take into account heterogeneity showed by I 2 and Cochran's Q values. A sensitivity analysis was conducted to exclude excessive influence by a single study. Evidence synthesis Among the papers identified, 29 were selected. A total of 3566 and 2556 cases formed the study population for assessment of the prevalence of residual tumor and upstaging, respectively. The corresponding numbers for the subgroup with detrusor muscle involvement at the initial TUR were 1565 and 1187. The pooled prevalence was 0.56 (95% confidence interval [CI] 0.48–0.63) for residual tumor and 0.1 (95% CI 0.06–0.14) for upstaging to T2 at reTUR. The corresponding rates for the detrusor muscle subgroup were 0.47 (95% CI 0.33–0.62) and 0.1 (95% CI 0.06–0.14). The sensitivity analysis excluded an excessive influence of each of the studies examined. Conclusions Pooled prevalence rates for residual tumor (∼50%) and upstaging to invasive disease (10%) at reTUR in T1 cases were high, and were stable among studies in different decades and for cases with detrusor muscle involvement at the initial TUR. Therefore, reTUR remains a fundamental procedure. Patient summary Repeat transurethral resection after a diagnosis of stage T1 bladder cancer is recommended given the high risk of misallocation to the proper treatment. |
| Databáze: | OpenAIRE |
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