Diabetes and Risk of Sudden Death in Coronary Artery Disease Patients Without Severe Systolic Dysfunction

Autor: Julie Pester, M.V. Moorthy, Alan H. Kadish, Christine M. Albert, Neal A. Chatterjee, Daniel C. Lee, Ramkumar V. Venkateswaran, Nancy R. Cook
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Left
Clinical Sciences
risk stratification
Coronary Artery Disease
Cardiorespiratory Medicine and Haematology
Cardiovascular
behavioral disciplines and activities
Sudden death
Risk Assessment
sudden cardiac death
Article
Ventricular Function
Left
Sudden cardiac death
Coronary artery disease
Cohort Studies
Clinical Research
Internal medicine
mental disorders
medicine
Diabetes Mellitus
Ventricular Function
Humans
HbA(1c)
Biologic marker
screening and diagnosis
Ejection fraction
business.industry
Prevention
Diabetes
Absolute risk reduction
Arrhythmias
Cardiac
Stroke Volume
medicine.disease
Atherosclerosis
Sudden
Death
Detection
Heart Disease
Death
Sudden
Cardiac
Relative risk
behavior and behavior mechanisms
Cardiology
Biomedical Imaging
business
Cardiac
psychological phenomena and processes
Cohort study
4.2 Evaluation of markers and technologies
Zdroj: JACC Clin Electrophysiol
JACC. Clinical electrophysiology, vol 7, iss 12
ISSN: 2405-5018
Popis: ObjectivesThis study sought to determine the absolute and relative associations of diabetes mellitus (DM) and hemoglobin A1c (HbA1c) with sudden and/or arrhythmic death (SAD) versus other modes of death in patients with coronary artery disease (CAD) who do not qualify for implantable cardioverter-defibrillators.BackgroundPatients with CAD and DM are at elevated risk for SAD; however, it is unclear whether these patients would benefit from implantable cardioverter-defibrillators given competing causes of death and/or whether HbA1c might augment SAD risk stratification.MethodsIn the PRE-DETERMINE study of 5,764 patients with CAD with left ventricular ejection fraction (LVEF) of >30% to 35%, competing risk analyses were used to compare the absolute and relative risks of SAD versus non-SAD by DM status and HbA1c level and to identify risk factors for SAD among 1,782 patients with DM.ResultsOver a median follow-up of 6.8 years, DM and HbA1c were significantly associated with SAD and non-SAD (P30% to 35%, patients with DM and/or elevated HbA1c are at much higher absolute risk of dying from non-SAD than SAD. Clinical risk markers, and not HbA1c, were associated with SAD risk in patients with DM. (PRE-DETERMINE: Biologic Markers and MRI SCD Cohort Study; NCT01114269).
Databáze: OpenAIRE
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