Pancreatic 18F-FDG uptake is increased in type 2 diabetes patients compared to non-diabetic controls
| Autor: | Hein J. Verberne, Daniël H. van Raalte, Max Nieuwdorp, Guido J. Bakker, Nyanza K. L. M. Timmers, Torsten P. M. Scheithauer, Hilde Herrema, C. Bruce Verchere, Manon C. Vanbellinghen, Erik S.G. Stroes |
|---|---|
| Přispěvatelé: | Vascular Medicine, ACS - Diabetes & metabolism, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, ACS - Atherosclerosis & ischemic syndromes, Graduate School, Experimental Vascular Medicine, Radiology and Nuclear Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male Physiology Type 2 diabetes 030204 cardiovascular system & hematology Pathology and Laboratory Medicine Gastroenterology Diagnostic Radiology 0302 clinical medicine Endocrinology Mathematical and Statistical Techniques Positron Emission Tomography Computed Tomography Medicine and Health Sciences Immune Response Tomography 2. Zero hunger Multidisciplinary medicine.diagnostic_test Organic Compounds Radiology and Imaging Muscles Statistics Monosaccharides Middle Aged Blood Sugar 3. Good health Type 2 Diabetes Body Fluids Chemistry medicine.anatomical_structure Blood Positron emission tomography Physical Sciences Medicine Regression Analysis Female medicine.symptom Anatomy Pancreas Research Article medicine.medical_specialty Endocrine Disorders Imaging Techniques Science Immunology Carbohydrates Blood sugar 030209 endocrinology & metabolism Inflammation Endocrine System Neuroimaging Linear Regression Analysis Research and Analysis Methods 03 medical and health sciences Signs and Symptoms Exocrine Glands Diagnostic Medicine Fluorodeoxyglucose F18 Diabetes mellitus Internal medicine medicine Diabetes Mellitus Humans Statistical Methods Aged Retrospective Studies business.industry Organic Chemistry Chemical Compounds Biology and Life Sciences Retrospective cohort study medicine.disease Glucose Cross-Sectional Studies Diabetes Mellitus Type 2 Metabolic Disorders Linear Models Radiopharmaceuticals business Body mass index Positron Emission Tomography Mathematics Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 3, p e0213202 (2019) PLoS ONE, 14(3). Public Library of Science |
| Popis: | IntroductionIncreasing evidence indicates that the development of type 2 diabetes is driven by chronic low grade beta-cell inflammation. However, it is unclear whether pancreatic inflammation can be noninvasively visualized in type 2 diabetes patients. We aimed to assess pancreatic 18F-FDG uptake in type 2 diabetes patients and controls using 18F-fluorodeoxylglucose positron emission tomography/computed tomography (18F-FDG PET/CT).Material and methodsIn this retrospective cross-sectional study, we enrolled 20 type 2 diabetes patients and 65 controls who had undergone a diagnostic 18F-FDG PET/CT scan and obtained standardized uptake values (SUVs) of pancreas and muscle. Pancreatic SUV was adjusted for background uptake in muscle and for fasting blood glucose concentrations.ResultsThe maximum pancreatic SUVs adjusted for background muscle uptake (SUVmax.m) and fasting blood glucose concentration (SUVglucose) were significantly higher in diabetes patients compared to controls (median 2.86 [IQR 2.24-4.36] compared to 2.15 [IQR 1.51-2.83], p = 0.006 and median 2.76 [IQR 1.18-4.34] compared to 1.91 [IQR 1.27-2.55], pConclusionPancreatic 18F-FDG uptake adjusted for background muscle uptake and fasting blood glucose concentration was significantly increased in type 2 diabetes patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|