Expression of histamine receptors (H1, H2, and H3) in the rabbit endolymphatic sac: an immunohistochemical study
| Autor: | Yildirim Bayazit, Celil Göçer, Nebil Göksu, Adil Eryilmaz, Muharrem Dagli, Gamze Mocan Kuzey, Banu Dogan Gun |
|---|---|
| Přispěvatelé: | Zonguldak Bülent Ecevit Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Pathology medicine.medical_specialty Membranous labyrinth Epithelium Endolymphatic sac Histamine receptor otorhinolaryngologic diseases medicine Animals Receptors Histamine H3 Receptors Histamine H2 Inner ear Receptors Histamine H1 Endolymphatic hydrops Receptor business.industry medicine.disease Immunohistochemistry medicine.anatomical_structure Otorhinolaryngology Rabbits sense organs Endolymphatic Sac business Immunostaining |
| Popis: | WOS: 000251743600004 PubMed: 18061827 Objective: The endolymphatic sac (ES) is part of the membranous labyrinth of the inner ear. Its central role in immunologic activity within the inner ear has been confirmed by numerous studies. The aim of this study was to investigate the expression of histamine receptors (H-1, H-2, H-3) in the rabbit ES. Methods: A total of 10 healthy male New Zealand white rabbits weighing 2 to 3 kg were used in the experiments. For immunohistochemical studies, immunostaining was performed according to the avidin-biotin-peroxidase complex technique. Results: Serial sections of the ES of rabbits revealed the presence of H-1, H-2, and H-3 receptor immunoreactivity. Immunoreactive cells for all H-1, H-2, and H-3 were found in the epithelial and subepithelial layers of the duct and the proximal ES. In conclusion, this study showed the immunohistochemical localization of H-1, H-2, and H-3 receptors in the ES of rabbits. These receptors may be important in the homeostasis of the inner ear. In addition, they may be target receptors in the medical treatment of inner car disorders such as endolymphatic hydrops. (C) 2008 Published by Elsevier Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|