Invasive pneumococcal disease in hospitalised children from Lima, Peru before and after introduction of the 7-valent conjugated vaccine
| Autor: | Isabel Reyes, M P Deza, Martha Egoavil, Francisco Campos, Roger Hernandez, Theresa J. Ochoa, Franco Castillo-Tokumori, K Sedano, Eduardo Chaparro, Maria E. Castillo, O Del Aguila, Andrés Sáenz, A Luna-Muschi, Wilda Silva, Erik Mercado |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Heptavalent Pneumococcal Conjugate Vaccine Epidemiology medicine.disease_cause purl.org/pe-repo/ocde/ford#3.03.09 [https] Pneumococcal conjugate vaccine Case fatality rate Peru pneumococcal infection serotype Prospective Studies Child child erythromycin resistance case fatality rate Incidence (epidemiology) Incidence Age Factors meningitis PCV7 Vaccination Pneumococcal infections Infectious Diseases female Streptococcus pneumoniae erythromycin Child Preschool Epidemiological Monitoring Female Meningitis pneumococcal conjugated vaccine medicine.drug prospective study medicine.medical_specialty Adolescent 030106 microbiology Erythromycin Serogroup Article Pneumococcal Infections 03 medical and health sciences male Internal medicine Drug Resistance Bacterial medicine pneumonia Humans controlled study human Original Paper child hospitalization business.industry bacterium isolate Pneumococcal conjugated vaccine Infant medicine.disease vaccination infant major clinical study Pneumococcus vaccine 030104 developmental biology incidence business trend study |
| Zdroj: | Epidemiology and Infection |
| ISSN: | 1469-4409 |
| Popis: | The objective of this study was to determine the serotype distribution and antibiotic resistance of invasive pneumococcal disease (IPD) strains in children from Lima, Peru, before and after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7), which was introduced in the national immunisation program on 2009. We conducted a prospective, multicentre, passive surveillance IPD study during 2006–2008 and 2009–2011, before and right after the introduction of PCV7 in Peru. The study was performed in 11 hospitals and five private laboratories in Lima, Peru, in patients Streptococcus pneumoniae. In total 159 S. pneumoniae isolates were recovered. There was a decrease in the incidence of IPD in children vs. 5.1/100 000, P = 0.004). Meningitis cases decreased significantly in the second period (P = 0.036) as well as the overall case fatality rate (P = 0.025), including a decreased case fatality rate of pneumonia (16.3% to 0%, P = 0.04). PCV7 serotypes showed a downward trend. Vaccine-preventable serotypes caused 78.9% of IPD cases, mainly 14, 6B, 5, 19F and 23F. A non-significant increase in erythromycin resistance was reported. Our findings suggest that the introduction of PCV7 led to a significant decrease of IPD in children under 2 years old and in the overall case fatality rate. |
| Databáze: | OpenAIRE |
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