Subtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection

Autor:	Tawanda Mandizvo, Nombali Gumede, Bongiwe Ndlovu, Siphiwe Ndlovu, Jaclyn K. Mann, Denis R. Chopera, Lanish Singh, Krista L. Dong, Bruce D. Walker, Zaza M. Ndhlovu, Christy L. Lavine, Michael S. Seaman, Kamini Gounder, Thumbi Ndung’u
Rok vydání:	2022
Předmět:	Epitopes Virology Insect Science Immunology HIV Seropositivity HIV-1 Humans HIV Infections HIV Antibodies Microbiology Antibodies Neutralizing Broadly Neutralizing Antibodies Phylogeny
Zdroj:	Journal of virology. 96(24)
ISSN:	1098-5514
Popis:	Broadly neutralizing antibodies (bNAbs) for HIV-1 prevention or cure strategies must inhibit transmitted/founder and reservoir viruses. Establishing sensitivity of circulating viruses to bNAbs and genetic patterns affecting neutralization variability may guide rational bNAbs selection for clinical development. We analyzed 326 single
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfae81221806138d825fbf66a9e4e78 https://pubmed.ncbi.nlm.nih.gov/36453881 Zobrazit plný text záznamu