A Novel Chemoattractant Lectin, Karatoxin, From the Dorsal Spines of the Small Scorpionfish Hypodytes rubripinnis
| Autor: | Mitsuko Shinohara, Hitomi Sakai, Koji Kato, Kiyoshi Ohura, Kozue Edo, Kuniko Nagasaka, Futoshi Iwaki, Haruhiko Sakuraba, Hideyuki Nakagawa |
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| Rok vydání: | 2010 |
| Předmět: |
Dorsum
Neutrophils Guinea Pigs Biology Hypodytes rubripinnis Chromatography Affinity Affinity chromatography Lectins Animals Glycoproteins Pharmacology chemistry.chemical_classification Molecular mass Hemagglutination Macrophages lcsh:RM1-950 Fishes Lectin Chemotaxis Molecular biology Chemotaxis Leukocyte Agglutination (biology) lcsh:Therapeutics. Pharmacology chemistry Biochemistry biology.protein Molecular Medicine Rabbits Glycoprotein |
| Zdroj: | Journal of Pharmacological Sciences, Vol 113, Iss 4, Pp 414-417 (2010) |
| ISSN: | 1347-8648 1347-8613 |
| Popis: | A chemoattractant lectin from the dorsal spines of the redfin velvetfish, Hypodytes rubripinnis, was isolated using a combination of affinity chromatography techniques. The glycoprotein, with a molecular mass of 110 kDa, is named Karatoxin. Karatoxin caused agglutination of rabbit erythrocytes. This agglutination was effectively inhibited by d-mannose. In addition, Karatoxin exhibited not only mitogenic activity in the presence of murine splenocytes, but also chemotactic activity in the presence of guinea-pig neutrophils and macrophages. Thus, Karatoxin appears to be a novel chemoattractant lectin. These results suggest that the redfin velvetfish Hypodytes rubripinnis may be a novel source of biologically active substances. Keywords:: chemoattractant lectin, Karatoxin, Hypodytes rubrinnis |
| Databáze: | OpenAIRE |
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