Influence of desmethylimipramine on some neurochemical alterations during experimental hypothyroidism
| Autor: | R.B. Rastogi, Radhey L. Singhal, P.D. Hrdina |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Serotonin Tyrosine 3-Monooxygenase Dopamine Tryptophan Hydroxylase Cellular and Molecular Neuroscience Norepinephrine chemistry.chemical_compound Neurochemical Hypothyroidism Pregnancy Internal medicine medicine Animals Pharmacology Brain Chemistry Methimazole Tyrosine hydroxylase Chemistry Dopaminergic Desipramine Brain Tryptophan hydroxylase Acetylcholinesterase Acetylcholine Rats Endocrinology Female medicine.drug |
| Zdroj: | Neuropharmacology. 14(10) |
| ISSN: | 0028-3908 |
| Popis: | Chemical thyroidectomy induced by administration of methimazole in neonatal rats reduced the activity of brain tyrosine hydroxylase and tryptophan hydroxylase as well as the levels of norepinephrine, dopamine and 5-hydroxytryptamine. However, the concentration of 5-hydroxyindoleacetic acid was markedly elevated. Whereas brain acetylcholine levels remained unaltered, the activity of its catabolizing enzyme, acetylcholinesterase, was significantly lowered by methimazole. Acute treatment with desmethylimipramine (10 mg kg , i.p.) suppressed the activity of tryptophan hydroxylase and the levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in both normal and hypothyroid rats. However, this tricyclic antidepressant failed to exert any appreciable effect on the amounts of norepinephrine, dopamine or acetylcholine in either group of animals. The data suggest that the responsiveness of the critical receptors at pre-and/or postsynaptic sites to the action of desmethylimipramine remains unaltered in hypothyroid rats. Furthermore, a possibility exists that the disturbed balance between central dopaminergic and cholinergic mechanisms might, at least in part, be associated with the aberrant behaviour and impaired psychomotor activity seen in the ‘cretinoid state’. |
| Databáze: | OpenAIRE |
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