Serum levels of beta-trace protein and glomerular filtration rate—preliminary results
| Autor: | Elena Donadio, M Ardini, Annalisa Lucchesi, Carlo Donadio, Roberto Giordani |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Clinical Biochemistry Pharmaceutical Science Renal function urologic and male genital diseases Analytical Chemistry Beta-Trace Protein chemistry.chemical_compound Reference Values Internal medicine Drug Discovery medicine Humans Cystatin C reproductive and urinary physiology Spectroscopy Aged Aged 80 and over Creatinine biology urogenital system Beta-2 microglobulin Chemistry Significant difference Middle Aged Cystatins Lipocalins female genital diseases and pregnancy complications Intramolecular Oxidoreductases Endocrinology Biochemistry biology.protein Female Kidney Diseases Cystatin beta 2-Microglobulin Quantitative analysis (chemistry) Glomerular Filtration Rate |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 32:1099-1104 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/s0731-7085(03)00215-2 |
| Popis: | The aim of this study was to evaluate the relationship between serum levels of beta-trace protein (BTP), a low molecular weight (MW) protein, and glomerular filtration rate (GFR). GFR and serum levels of BTP, and for comparison creatinine (Creat), cystatin C (Cys) and β2-microglobulin (β2M), were measured in 60 patients, with renal function ranging from normality to advanced renal failure. Serum levels of BTP progressively increased with the reduction of GFR. A good correlation was found between GFR and serum levels of BTP ( r =0.918), Creat ( r =0.932), Cys ( r =0.937), and β2M ( r =0.924). Furthermore, no statistically significant difference was found between BTP and Creat, Cys, β2M, as indicators of a moderate GFR impairment. These preliminary data indicate that BTP might be suitable as an indicator of GFR. |
| Databáze: | OpenAIRE |
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