Echinococcus multilocularis: in vitro interactions between protoscolices and Kupffer cells
| Autor: | Marc Mesnil, S. Walbaum, Claude Gabrion, Anne-Françoise Pétavy, S. Al Nahhas |
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| Rok vydání: | 1994 |
| Předmět: |
Pathology
medicine.medical_specialty Kupffer Cells Mice Inbred Strains Echinococcus multilocularis Glycocalyx Mice Phagocytosis Polysaccharides medicine Cell Adhesion Animals Cells Cultured Glycoproteins General Veterinary biology Kupffer cell Rats Inbred Strains General Medicine Viral tegument biology.organism_classification Molecular biology In vitro Echinococcus Rats Microscopy Electron Infectious Diseases medicine.anatomical_structure Liver Cell culture Insect Science Ultrastructure Hepatic stellate cell Parasitology Gerbillinae |
| Zdroj: | Parasitology research. 80(5) |
| ISSN: | 0932-0113 |
| Popis: | Echinococcus multilocularis protoscolices collected from experimentally infected jirds were incubated for 2 weeks in rat hepatic cell cultures cocultivated with or without feeder cells (BALB/c 3T3 and IAR 20). Scanning and transmission electron microscopy studies were performed during the course of the culture period. Kupffer cells (Kc) were seen adhering to the anterior and posterior ends of the protoscolices. Some protoscolices were fixed to the cell monolayer by a cluster of Kc adhering to the posterior end of the parasite. These cells were phagocytosing the glycocalyx and the electron-dense distal end of the microthrix of the protoscolex tegument. An alteration in the superficial tegumental cytoplasm with extensive mitochondrial damage was also noted. The properties expressed by Kc against protoscolices in vitro might also be relevant for proliferation of metacestodes in vivo. |
| Databáze: | OpenAIRE |
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