The Prognostic Significance of Nonsentinel Lymph Node Metastasis in Melanoma
| Autor: | Kelly M. McMasters, Russell E. Brown, R. Dirk Noyes, Merrick I. Ross, Douglas S. Reintgen, Michael J. Edwards, Lee Hagendoorn, Charles R. Scoggins, Arnold J. Stromberg, Robert C.G. Martin |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Adolescent medicine.medical_treatment Sentinel lymph node Gastroenterology Metastasis Breslow Thickness Young Adult Internal medicine Humans Medicine Prospective Studies Melanoma Lymph node Survival rate Aged Univariate analysis Sentinel Lymph Node Biopsy business.industry Middle Aged Prognosis medicine.disease Survival Rate medicine.anatomical_structure Oncology Lymphatic Metastasis Lymph Node Excision Female Surgery Lymphadenectomy Lymph Nodes business Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology. 17:3330-3335 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-010-1208-8 |
| Popis: | We hypothesized that metastasis beyond the sentinel lymph nodes (SLN) to the nonsentinel nodes (NSN) is an important predictor of survival. Analysis was performed of a prospective multi-institutional study that included patients with melanoma ≥1.0 mm in Breslow thickness. All patients underwent SLN biopsy; completion lymphadenectomy was performed for all SLN metastases. Disease-free survival (DFS) and overall survival (OS) were computed by Kaplan–Meier analysis; univariate and multivariate analyses were performed to identify factors associated with differences in survival among groups. A total of 2335 patients were analyzed over a median follow-up of 68 months. We compared 3 groups: SLN negative (n = 1988), SLN-only positive (n = 296), and both SLN and NSN positive (n = 51). The 5-year DFS rates were 85.5, 64.8, and 42.6% for groups 1, 2, and 3, respectively (P |
| Databáze: | OpenAIRE |
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