EXPERIENCE WITH HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN PATIENTS WITH HEPATITIS B VIRUS AND HEPATITIS DELTA VIRUS INFECTIONS IN LOS ANGELES, 1977–1985
| Autor: | Alan G. Redeker, Kathleen Shriver, Sugantha Govindarajan, Hsiao-Ping Lu, Virginia M. Edwards, Joyce C. Niland, Afsaneh Rahimian, Kevin M. De Cock |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Epidemiology Human immunodeficiency virus (HIV) Enzyme-Linked Immunosorbent Assay medicine.disease_cause California Virus Serology Internal medicine HIV Seropositivity Humans Medicine Serologic Tests Seroconversion Child Hepatitis B virus Hepatitis biology business.industry Homosexuality Hepatitis B medicine.disease Virology Hepatitis D Natural history Acute Disease Chronic Disease biology.protein Female Antibody Epidemiologic Methods business |
| Zdroj: | American Journal of Epidemiology. 127:1250-1260 |
| ISSN: | 1476-6256 0002-9262 |
| DOI: | 10.1093/oxfordjournals.aje.a114917 |
| Popis: | Stored serum specimens from 723 patients with acute hepatitis B and 228 patients with chronic hepatitis B seen between 1977 and 1985 in the Hepatitis Clinic of the Los Angeles County-University of Southern California Medical Center, Los Angeles, CA, were tested for antibody to human immunodeficiency virus (anti-HIV). Risk factors were ordered hierarchically; cases with multiple risk factors were tabulated only in the risk group listed first on the clinic records. Anti-HIV was first detected in 1979, and by 1983 was found in about half of all homosexual men with chronic hepatitis B. The prevalence was significantly lower in patients with acute hepatitis B than in patients with chronic hepatitis B, and in nonhomosexual subjects compared with homosexual subjects. By 1985, 30 per cent of intravenous drug users with chronic hepatitis B were anti-HIV-positive. The highest annual seroconversion rate for anti-HIV, 21 per cent, was found in homosexual men in 1983. A significant association existed between anti-HIV positivity and hepatitis delta virus infection in homosexual men but not in drug abusers. This study provides data on the natural history of the human immunodeficiency virus epidemic in Los Angeles. Further study on the interaction of these different viruses is warranted. |
| Databáze: | OpenAIRE |
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