Reovirus-induced liver disease in severe combined immunodeficient (SCID) mice. A model for the study of viral infection, pathogenesis, and clearance
| Autor: | C L Witzleben, John J. Cebra, S. I. Kost, Donald H. Rubin, A. George |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adoptive cell transfer
Immunology Biology Reoviridae Virus Pathogenesis Sepsis Mice Peyer's Patches Liver disease Immune system medicine Animals Immunology and Allergy Antigens Viral Mice Inbred BALB C Liver Diseases Immunologic Deficiency Syndromes Peyer's patch Articles medicine.disease Virology Mice Mutant Strains Reoviridae Infections Disease Models Animal medicine.anatomical_structure Viral disease |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Adult severe combined immunodeficient (SCID) mice can be infected by the oral route with reovirus, and a systemic infection can be established. Infectious virus is recovered from all internal organs, and the mice die in 4-6 wk. Chronic, discrete inflammatory lesions appear in the liver of infected mice, and are associated with hepatocytes containing demonstrable levels of viral antigen. The adoptive transfer of Peyer's patch (PP) cells from congenic mice before infection protects the SCID mice against disease and death. Immune donor PP cells can be distinguished from nonimmune cells by their ability to contain and resolve infection by 1 wk after challenge. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|