Placental SARS‐CoV‐2 in a Pregnant Woman with Mild COVID‐19 Disease
| Autor: | Nabila Khaleel, Albert L. Hsu, Xiu-Feng Wan, Breanna C. Tuhlei, Amanda J. Stephens, Eric Johannesen, Nikki Kagan, Minhui Guan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty SARS coronavirus < Virus classification medicine.medical_treatment Placenta Disease medicine.disease_cause Coronavirus < Virus classification Virus Public policy < Social Science 03 medical and health sciences 0302 clinical medicine Pregnancy Virology medicine Humans 030212 general & internal medicine Pregnancy Complications Infectious Antigens Viral Research Articles Coronavirus Fetus Obstetrics business.industry SARS-CoV-2 COVID-19 Endothelial Cells medicine.disease Infectious Disease Transmission Vertical Trophoblasts medicine.anatomical_structure Infectious Diseases Labor induction COVID-19 Nucleic Acid Testing Chorionic villi 030211 gastroenterology & hepatology Female Pregnant Women Chorionic Villi business Research Article |
| Zdroj: | Journal of Medical Virology |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | Background The full impact of COVID‐19 on pregnancy remains uncharacterized. Current literature suggests minimal maternal, fetal, and neonatal morbidity and mortality.1 COVID‐19 manifestations appear similar between pregnant and non‐pregnant women.2 Objectives/Study Design We present a case of placental SARS‐CoV‐2 virus in a woman with mild COVID‐19 disease, then review the literature. RT‐PCR was performed to detect SARS‐CoV‐2. Immunohistochemistry staining was performed with specific monoclonal antibodies to detect SARS‐CoV‐2 antigen or to identify trophoblasts. Results A 29 year‐old multigravida presented at 40‐4/7 weeks for labor induction. With myalgias two days prior, she tested positive for SARS‐CoV‐2. We demonstrate maternal vascular malperfusion, with no fetal vascular malperfusion, as well as SARS‐CoV‐2 virus in chorionic villi endothelial cells, and also rarely in trophoblasts. Conclusions To our knowledge, this is the first report of placental SARS‐CoV‐2 despite mild COVID‐19 disease (no symptoms of COVID‐19 aside from myalgias); patient had no fever, cough, or shortness of breath, but only myalgias and sick contacts. Despite her mild COVID‐19 disease in pregnancy, we demonstrate placental vasculopathy and presence of SARS‐CoV‐2 virus across the placenta. Evidence of placental COVID‐19 raises concern for placental vasculopathy (potentially leading to fetal growth restriction and other pregnancy complications) and possible vertical transmission – especially for pregnant women who may be exposed to COVID‐19 in early pregnancy. This raises important questions of whether future pregnancy guidance should include stricter pandemic precautions, such as screening for a wider array of COVID‐19 symptoms, increased antenatal surveillance, and possibly routine COVID‐19 testing throughout pregnancy. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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