Sequential Subcutaneous Thymopentin, Interferon Alpha-2A and Interleukin-2 in Metastatic Renal Cell Cancer
| Autor: | Silvia Carpano, M. Lopez, L. Di Lauro, P Del Medico, T. Gionfra, M. Rosselli, Patrizia Vici, A. Cancrini |
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| Přispěvatelé: | Iaffaioli, R. V., Tortoriello, A., Facchini, G., Caponigro, F., Marzano, N., Bucci, L., Fei, Landino, Santangelo, M. |
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Interleukin 2 Cancer Research Injections Subcutaneous interferon alpha-2a Interferon alpha-2 Pharmacology renal cell cancer Drug Administration Schedule 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Interferon Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Thymopentin Metastatic renal cell cancer Carcinoma Renal Cell Interferon Alpha 2a Aged business.industry Interferon-alpha Drug Synergism General Medicine Middle Aged medicine.disease Kidney Neoplasms Recombinant Proteins Clinical trial Oncology 030220 oncology & carcinogenesis Toxicity Immunology Interleukin-2 Female business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 2038-2529 0300-8916 |
| Popis: | To determine the activity of sequential administration of thymopentin (TP-5), interferon alpha-2a (IFN) and interleukin-2 (IL-2) in metastatic renal cell cancer (RCC), 17 patients with RCC were treated with TP-5 50 mg/d on days 1 to 14, IFN 3 MIU/d on days 14, 15, 21, 22 and IL-2 18 MIU/d on days 16 to 20, and 23 to 27. Treatment was given subcutaneously and cycles were repeated every 6 weeks. All patients were assessed for toxicity and response. No objective responses were observed. Two patients had a short-lived disease stabilization. Median survival was 9 months. Toxicity was generally moderate. The most important side-effects were related to IL-2 administration. In view of the lack of antitumor activity, the combination of TP-5 + IFN + IL-2 in the doses and schedule used in this trial cannot be recommended. The investigation of chemotherapeutic and immunological agents that can effectively synergize with IFN or IL-2 is essential. |
| Databáze: | OpenAIRE |
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