Regional Differences in the Contributions of TNF Reverse and Forward Signaling to the Establishment of Sympathetic Innervation
Autor: | Clara Erice, Alun M. Davies, O. Yipkin Calhan, Sean Wyatt, Lilian Kisiswa |
---|---|
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Superior cervical ganglion TNF Regulator Spleen Biology 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience In vivo Neural Pathways sympathetic innervation medicine Animals development Cells Cultured Research Articles Mice Knockout Ganglia Sympathetic sympathetic neuron Tumor Necrosis Factor-alpha Axons In vitro Cell biology TNFR1 030104 developmental biology medicine.anatomical_structure nervous system Prevertebral ganglia Receptors Tumor Necrosis Factor Type I Tumor necrosis factor alpha Sympathetic innervation 030217 neurology & neurosurgery Signal Transduction Research Article |
Zdroj: | Erice, C, Calhan, O Y, Kisiswa, L, Wyatt, S & Davies, A M 2019, ' Regional Differences in the Contributions of TNF Reverse and Forward Signaling to the Establishment of Sympathetic Innervation ', Developmental Neurobiology, vol. 79, no. 4, pp. 317-334 . https://doi.org/10.1002/dneu.22680 Developmental Neurobiology |
ISSN: | 1932-846X 1932-8451 |
Popis: | Members of the TNF and TNF receptor superfamilies acting by both forward and reverse signaling are increasingly recognized as major physiological regulators of axon growth and tissue innervation in development. Studies of the experimentally tractable superior cervical ganglion (SCG) neurons and their targets have shown that only TNF reverse signaling, not forward signaling, is a physiological regulator of sympathetic innervation. Here, we compared SCG neurons and their targets with prevertebral ganglion (PVG) neurons and their targets. Whereas all SCG targets were markedly hypoinnervated in both TNF‐deficient and TNFR1‐deficient mice, PVG targets were not hypoinnervated in these mice and one PVG target, the spleen, was significantly hyperinnervated. These in vivo regional differences in innervation density were related to in vitro differences in the responses of SCG and PVG neurons to TNF reverse and forward signaling. Though TNF reverse signaling enhanced SCG axon growth, it did not affect PVG axon growth. Whereas activation of TNF forward signaling in PVG axons inhibited growth, TNF forward signaling could not be activated in SCG axons. These latter differences in the response of SCG and PVG axons to TNF forward signaling were related to TNFR1 expression, whereas PVG axons expressed TNFR1, SCG axons did not. These results show that both TNF reverse and forward signaling are physiological regulators of sympathetic innervation in different tissues. |
Databáze: | OpenAIRE |
Externí odkaz: |