Tumor suppression effects of myoepithelial cells on mice breast cancer
| Autor: | Mahmood Khaniki, Ali Mohammad Alizadeh, Mostafa Latifpour, Sarieh Ghasempour, Baharak Farhanji, Hamid Khodayari, Saeed Khodayari |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Cell Survival Cell Transplantation Biology Adenocarcinoma Mice Breast cancer Mammary Glands Animal Microscopy Electron Transmission Cell Line Tumor medicine Animals Viability assay Pharmacology Mice Inbred BALB C Maspin Myoepithelial cell Mammary Neoplasms Experimental Epithelial Cells medicine.disease Flow Cytometry Coculture Techniques Blood chemistry Cancer cell Immunohistochemistry RNA Female |
| Zdroj: | European journal of pharmacology. 765 |
| ISSN: | 1879-0712 |
| Popis: | Several studies have assumed that myoepithelial cells (MECs) loss may contribute to epithelial tumor induction and/or progression. We adopted an in vitro assay and a syngeneic mice breast cancer model with histological and molecular characteristics resembling human lesions to evaluate tumor suppression effects of MECs. Flow cytometric, cell viability, blood chemistry, transmission electron microscope, immunohistochemistry and qRT-PCR assays were performed at the end of the study. We demonstrated that MECs could significantly suppress the viability of cancer cells at different time points (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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