Association study between glutathione S-transferase GST-M1, GST-T1, and GST-P1 polymorphisms and tardive dyskinesia
| Autor: | Seung Gul Kang, Leen Kim, Jung Eun Choi, Min Kyu Rhee, Heon Jeong Lee, Hyonggin An |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Dyskinesia Drug-Induced Pharmacology Biology Tardive dyskinesia medicine.disease_cause Polymerase Chain Reaction Severity of Illness Index chemistry.chemical_compound Genotype medicine Humans Genetic Predisposition to Disease Pharmacology (medical) Poisson Distribution Gene Glutathione Transferase Genetics Korea Polymorphism Genetic Multifactor dimensionality reduction Glutathione Middle Aged medicine.disease Oxidative Stress Psychiatry and Mental health Glutathione S-transferase Glutathione S-Transferase pi Neurology Dyskinesia chemistry Schizophrenia biology.protein Female Neurology (clinical) medicine.symptom Oxidative stress Antipsychotic Agents |
| Zdroj: | Human Psychopharmacology: Clinical and Experimental. 24:55-60 |
| ISSN: | 1099-1077 0885-6222 |
| DOI: | 10.1002/hup.988 |
| Popis: | Objectives Data from several studies suggest that oxidative stress may play a role in the pathophysiology of tardive dyskinesia (TD). Glutathione S-transferase (GST) enzymes play important roles in protecting cells against oxidative stress. In the present study, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes can influence susceptibility to TD in patients with schizophrenia. Methods The GST-M1, GST-T1, and GST-P1 loci were analyzed by polymerase chain reaction (PCR)-based methods in 83 schizophrenic patients with TD and 126 schizophrenic without TD who were matched for antipsychotic drug exposure and other relevant variables. The multifactor dimensionality reduction (MDR) approach was used to analyze gene–gene interactions. Results There were no significant differences in the distributions of the GST-M1, GST-T1, and GST-P1 genotypes between the TD and non-TD groups (p > 0.05). However, in comparison of the severity of TD among genotypes using Poisson regression showed that Ile/Ile genotype of GST-P1 had higher AIMS score compared to Ile/Val + Val/Val genotypes (X2 = 7.13, p = 0.008). MDR analysis did not show a significant interaction between the three GST gene variants and susceptibility to TD (p > 0.05). Conclusions These results suggest that GST gene polymorphisms do not confer increased susceptibility to TD in patients with schizophrenia but TD severity might be related with GST-P1 variants. Copyright © 2008 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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