White matter volume alterations in hair-pulling disorder (trichotillomania)
| Autor: | Lian Taljaard, Angelo Dias, Samantha J. Brooks, Dan J. Stein, Anne Uhlmann, Christine Lochner |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Cognitive Neuroscience BF Audiology Grey matter Impulsivity 050105 experimental psychology Trichotillomania White matter 03 medical and health sciences Behavioral Neuroscience Cellular and Molecular Neuroscience 0302 clinical medicine Neuroimaging Humans Medicine 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Gray Matter business.industry 05 social sciences Neuropsychology Brain Voxel-based morphometry medicine.disease Magnetic Resonance Imaging White Matter Psychiatry and Mental health Hair loss medicine.anatomical_structure nervous system Neurology RC0321 Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Parahippocampal gyrus |
| Zdroj: | Brain Imaging and Behavior. 14:2202-2209 |
| ISSN: | 1931-7565 1931-7557 2162-3279 |
| DOI: | 10.1007/s11682-019-00170-z |
| Popis: | Trichotillomania (TTM) is a disorder characterized by repetitive hair-pulling resulting in hair loss. Key processes affected in TTM comprise affective, cognitive, and motor functions. Emerging evidence suggests that brain matter aberrations in fronto-striatal and fronto-limbic brain networks and the cerebellum may characterize the pathophysiology of TTM. The aim of the present voxel-based morphometry (VBM) study was to evaluate whole brain grey and white matter volume alteration in TTM and its correlation with hair-pulling severity. High-resolution magnetic resonance imaging (3 T) data were acquired from 29 TTM patients and 28 age-matched healthy controls (CTRLs). All TTM participants completed the Massachusetts General Hospital Hair-Pulling Scale (MGH-HPS) to assess illness/pulling severity. Using whole-brain VBM, between-group differences in regional brain volumes were measured. Additionally, within the TTM group, the relationship between MGH-HPS scores, illness duration and brain volumes were examined. All data were corrected for multiple comparisons using family-wise error (FWE) correction at p |
| Databáze: | OpenAIRE |
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