Clinical, Radiographic, and Pathologic Features of Medial Calcific Sclerosis in the Breast

Autor:	Peter J. Kragel, Fiorella R, Aquino Mo, Chapman J
Rok vydání:	1997
Předmět:	Adult Breast biopsy Pathology medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Malignancy behavioral disciplines and activities Biopsy Humans Medicine Mammography Breast Retrospective Studies Sclerosis medicine.diagnostic_test business.industry Lumpectomy Calcinosis General Medicine medicine.disease humanities Female Microcalcification medicine.symptom Tunica Media business Mastectomy Calcification
Zdroj:	Southern Medical Journal. 90:518-521
ISSN:	0038-4348
DOI:	10.1097/00007611-199705000-00011
Popis:	Medial calcific sclerosis (MCS), a nonocclusive calcification of the media of small to medium-sized muscular arteries, may occur in the breast. To ascertain whether MCS causes difficulty with mammographic interpretation of breast calcifications and to determine its clinical and pathologic associations, we reviewed the records and biopsy specimens from 62 patients who had had screening mammography and breast biopsy, lumpectomy, or mastectomy. Ten specimens from 7 patients showed MCS. Average age of patients without MCS was 48.8 years, and that of the 7 patients with MCS was 61.3 years. Microcalcifications were found in 25 of 62 mammograms (34%). Of the 7 patients with MCS, 2 had hypertension, 1 diabetes mellitus, 2 diabetes mellitus and hypertension, and 2 neither hypertension nor diabetes mellitus. In 5 specimens, calcification only was associated with MCS. In 2 of these specimens, the mammographic calcifications were thought to be suggestive of malignancy on the basis of clustering and spiculation. One of the 2 was benign on histopathology; the other was malignant. Overall, carcinoma was identified in 3 of 7 patients with MCS (compared with 11 of 55 patients without MCS) and in 2 of 5 specimens (2 patients) with mammary MCS as the only type of calcification. The mammographic appearance of the microcalcification in MCS may suggest malignancy.
Databáze:	OpenAIRE
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