Apolipoprotein E polymorphism and lipoprotein compositions in normolipidaemic xanthelasma patients
| Autor: | Lülüfer Tamer, Gulcin Eskandari, Tamer Irfan Kaya, Ugur Atik, Ümit Türsen, Guliz Ikizoglu |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Apolipoprotein E medicine.medical_specialty Very low-density lipoprotein Turkey Apolipoprotein B Lipoproteins Dermatology Apolipoproteins A White People Apolipoproteins E chemistry.chemical_compound Internal medicine Xanthomatosis Humans Medicine Triglycerides Apolipoproteins B Polymorphism Genetic biology business.industry Cholesterol Cholesterol HDL Cholesterol LDL Middle Aged medicine.disease Infectious Diseases Xanthelasma Endocrinology chemistry Case-Control Studies biology.protein Female lipids (amino acids peptides and proteins) business Lipoprotein |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology. 20:260-263 |
| ISSN: | 1468-3083 0926-9959 |
| DOI: | 10.1111/j.1468-3083.2006.01418.x |
| Popis: | Background Apolipoprotein E (apoE) phenotypes and lipoprotein compositions in xanthelasma patients have been reported in different series. Objective To investigate the apoE polymorphism and lipoprotein compositions in xanthelasma patients by using rapid polymerase chain reaction, and searched for an association between apoE polymorphism and the lipoprotein levels in xanthelasma patients. Design ApoE polymorphism and the different types of serum lipoproteins were studied in 25 patients with xanthelasma and compared with 27 normal subjects. Results All of patients were found to be normolipidaemic. The patients had significantly higher concentrations of total cholesterol and apolipoprotein B, and lower concentrations of apolipoprotein A. There was no difference in serum triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol concentrations. The distribution of apoE genotypes and alleles was the same in both groups. Conclusions The apoB, apoA and cholesterol levels did show statistically significant differences in the direction of an increased risk of atherosclerosis. Patients with xanthelasma demonstrated slight differentiations in the apoE polymorphism and metabolism of lipoproteins that require further clarifications. |
| Databáze: | OpenAIRE |
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