The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction
| Autor: | Radina Droumeva, Nazmul Huda, Satoshi Abe, Ryan R. Brinkman, Peter M. Lansdorp, Connie J. Eaves, David Gilley, Elizabeth A. Chavez, Nagarajan Kannan, Geraldine Aubert, Joanne T. Emerman, LiRen Tu |
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| Přispěvatelé: | Damage and Repair in Cancer Development and Cancer Treatment (DARE) |
| Rok vydání: | 2013 |
| Předmět: |
EXPRESSION
Adult Adolescent DNA damage Mammary gland Population Biology Biochemistry Report Genetics medicine LENGTH Humans Progenitor cell CANCER-CELLS education Mammary Glands Human Telomerase Cells Cultured Telomere Shortening Aged REPAIR education.field_of_study FLOW-CYTOMETRY MRN COMPLEX EPITHELIAL-CELLS Cell Biology ASSOCIATION Middle Aged Telomere Cell biology Adult Stem Cells medicine.anatomical_structure MRN complex DNA-DAMAGE Cancer cell Immunology Female Stem cell STEM-CELLS Developmental Biology DNA Damage |
| Zdroj: | Stem Cell Reports Stem Cell Reports, 1(1), 28-37. CELL PRESS |
| ISSN: | 2213-6711 |
| Popis: | Telomeres are essential for genomic integrity, but little is known about their regulation in the normal human mammary gland. We now demonstrate that a phenotypically defined cell population enriched in luminal progenitors (LPs) is characterized by unusually short telomeres independently of donor age. Furthermore, we find that multiple DNA damage response proteins colocalize with telomeres in >95% of LPs but in Graphical Abstract Highlights • Normal human mammary gland luminal progenitors (LPs) have very short telomeres • LP nuclei selectively exhibit telomere-associated DNA damage responses • LPs have selectively elevated hTERT expression and telomerase activity • These LP features may play a role in mammary tissue homeostasis and transformation |
| Databáze: | OpenAIRE |
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