Galectina-3 circulante tras el trasplante cardiaco: dinámica a largo plazo y valor pronóstico
| Autor: | Paula Blanco-Canosa, José Manuel Vázquez-Rodríguez, Javier Muñiz, Natalia Suárez-Fuentetaja, Gonzalo Barge-Caballero, David Couto-Mallón, María J. Paniagua-Martín, María G. Crespo-Leiro, Francisco Estévez-Cid, Miguel Solla-Buceta, Eduardo Barge-Caballero, Z. Grille-Cancela, José J. Cuenca-Castillo, Nieves Doménech, Jorge Pombo-Otero, Antoni Bayes-Genis, Lucía Moreda-Santamaría |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Graft Rejection
Male Trasplante cardiaco medicine.medical_specialty Time Factors Galectin 3 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Immune system Risk Factors Cause of Death Internal medicine Galectina-3 Clinical endpoint Humans Galectin-3 Medicine In patient Retrospective Studies Cardiovascular mortality business.industry Proportional hazards model Incidence Pronóstico General Medicine Middle Aged Prognosis medicine.disease ROC Curve Spain Heart failure Heart Transplantation Biomarker (medicine) Female Heart transplant business Biomarkers Follow-Up Studies |
| Zdroj: | RUC. Repositorio da Universidade da Coruña instname Revista Espanola de Cardiologia r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol |
| ISSN: | 1885-5857 0300-8932 |
| Popis: | [Abstract] Introduction and objectives: Circulating galectin-3 (Gal-3) is elevated and significantly correlates with all-cause and cardiovascular mortality in patients with heart failure. However, the relationship between serum Gal-3 and heart transplant (HT) outcomes is unclear. The aim of this study was to describe the longitudinal trend and prognostic value of Gal-3 levels after HT. Methods: Banked serum samples were available from 122 HT recipients, collected before transplant and at 1, 3, 6, and 12 months posttransplant. Gal-3 levels in these serum samples were measured by enzyme immune assay. Multivariable Cox regression was performed to determine the prognostic value of 12-month posttransplant Gal-3 serum levels. The primary endpoint was the composite variable all-cause death or graft failure over long-term posttransplant follow-up. Results: Circulating Gal-3 concentration steadily decreased during the first year after HT (median values: pretransplant, 19.1 ng/mL; 1-year posttransplant, 14.6 ng/mL; P |
| Databáze: | OpenAIRE |
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