Advanced Glycation End Product Accumulation is Associated with Lower Cognitive Performance in an Older General Population: The Nagahama Study

Autor: Takahisa Kawaguchi, Kazuya Setoh, Yasuharu Tabara, Mikihiro Yamanaka, Shinji Kosugi, Fumihiko Matsuda, Hiroaki Segawa, Takeo Nakayama
Rok vydání: 2020
Předmět:
Glycation End Products
Advanced
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Population
Neuropsychological Tests
Fluorescence
Fingers
03 medical and health sciences
chemistry.chemical_compound
Cognition
0302 clinical medicine
Japan
Risk Factors
Glycation
Internal medicine
medicine
Humans
Dementia
Effects of sleep deprivation on cognitive performance
Cognitive decline
Risk factor
education
Aged
Skin
education.field_of_study
business.industry
General Neuroscience
General Medicine
Middle Aged
medicine.disease
Psychiatry and Mental health
Clinical Psychology
Cross-Sectional Studies
030104 developmental biology
chemistry
Educational Status
Advanced glycation end-product
Female
Geriatrics and Gerontology
Cognition Disorders
business
Psychomotor Performance
030217 neurology & neurosurgery
Zdroj: Journal of Alzheimer's Disease. 74:741-746
ISSN: 1875-8908
1387-2877
DOI: 10.3233/jad-190878
Popis: Accumulation of advanced glycation end products (AGEs) has been linked with cognitive decline as a risk factor based on the analysis in small populations. We investigated the association between skin autofluorescence of AGEs and global cognitive function in a Japanese older (≥60 years) population (n = 4,041). The AGEs quartiles were inversely associated with the Revised Hasegawa's Dementia Scale score (Q1: reference, Q2: β= -0.011, p = 0.537, Q3: β= -0.043, p = 0.016, Q4: β= -0.064, p < 0.001) independent of major risk factors. Accumulation of AGEs was associated with lower cognitive performance in older adults.
Databáze: OpenAIRE
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