Reduction in formation of peritoneal adhesions by methylene blue in rats: a dose response study
| Autor: | Micha Rabau, Ron Ben-Avraham, Yair Galili, Yoram Kluger, Avi A. Weinbroum, Joseph M. Klausner |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Anterior wall Adhesion (medicine) Tissue Adhesions Peritoneal Diseases Peritoneal adhesions chemistry.chemical_compound Random Allocation Postoperative Complications Abdomen medicine Animals Rats Wistar Saline Dose-Response Relationship Drug business.industry Uterine horns medicine.disease Effective dose (pharmacology) Dose Response Study Surgery Rats Methylene Blue chemistry Female business Methylene blue Injections Intraperitoneal |
| Zdroj: | The European journal of surgery = Acta chirurgica. 166(7) |
| ISSN: | 1102-4151 |
| Popis: | Objective: To find out if the ability of methylene blue given intraperitoneally to reduce surgically-induced adhesions in rats is concentration dependent.Design: Random, controlled prospective study.Setting: Teaching hospital, Israel.Animals: Seventy female Wistar rats.Interventions: Intraperitoneal adhesions were generated in rats by scraping the anterior wall of the uterine horn. They were then given either saline or serially diluted methylene blue intraperitoneally. Additional rats received identical treatments, but without the serosal damage.Outcome measures: Graded formation of adhesions, two weeks later.Results: In the rats treated with methylene blue 1%, adhesion formation was similar to that in sham operated rats and was significantly lower (p < 0.001) than in all other groups.Conclusion: Methylene blue 1%, and to lesser degree 0.5%, had the best anti-adhesion potential. Lower methylene blue concentrations were only partially effective, and much high concentrations may cause adverse effects. |
| Databáze: | OpenAIRE |
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