Rhabdomyolysis: A rare adverse effect of diphenhydramine overdose
| Autor: | Robert D Herr, Seyed M. Emadian, E. Martin Caravati |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_treatment Suicide Attempted Drug overdose Rhabdomyolysis medicine Humans Adverse effect Coma business.industry Diphenhydramine Myoglobinuria General Medicine medicine.disease Anesthesia Toxicity Histamine H1 Antagonists Emergency Medicine Antihistamine Drug Overdose medicine.symptom business medicine.drug |
| Zdroj: | The American Journal of Emergency Medicine. 14:574-576 |
| ISSN: | 0735-6757 |
| Popis: | Drug- and toxin-induced rhabdomyolysis is a nonspecific clinical syndrome resulting from the release of skeletal muscle cell contents into the plasma and urine. Antihistamine drugs are the active ingredients in a number of over-the-counter preparations and are frequently ingested in suicide attempts. We report rhabdomyolysis as a rare adverse effect of diphenhydramine toxicity in a 29-year-old man who ingested an unknown quantity of an over-the-counter sleep preparation in a suicide attempt. The patient had documented toxic concentration of diphenhydramine in his cerebrospinal fluid and no history of seizures, coma, or hypothermia. A high index of suspicion and an evaluation for rhabdomyolysis is warranted in antihistamine toxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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