Rapidly fatal pulmonary fibrosis: the accelerated variant of interstitial pneumonitis
| Autor: | D S Pratt, J J May, R B Dreisin, M I Schwartz |
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| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Pathology Pulmonary Fibrosis Immunoglobulins Gastroenterology Arthritis Rheumatoid Rheumatoid Factor Fibrosis Internal medicine Pulmonary fibrosis medicine Humans Immune Complex Diseases Rheumatoid factor Eosinophilia Lung Aged Systemic lupus erythematosus business.industry Collagen Diseases Interstitial lung disease Middle Aged medicine.disease Antibodies Antinuclear Rheumatoid arthritis Female medicine.symptom business Immune complex disease Research Article |
| Zdroj: | Thorax. 34:587-593 |
| ISSN: | 0040-6376 |
| DOI: | 10.1136/thx.34.5.587 |
| Popis: | We sought to explore immunological factors in patients who died with rapidly fatal fibrosing lung diseases (Hamman-Rich syndrome). A retrospective review of cases of interstitial lung disease showed 12 recent deaths from Hamman-Rich syndrome. The mean age was 62, men outnumbering women 3 : 1. Five patients had proved collagen vascular disease (rheumatoid arthritis three, lupus two). Four others had a history of allergic disorders, syphilis, chronic eosinophilia, or hypersensitivity reactions. One patient showed disappearance of immunofluorescence as fibrosis advanced, which has not previously been reported. The study suggests a possible aetiological link between disorders of immunity and Hamman-Rich syndrome. The evidence also supports the notion that Hamman-Rich syndrome is an accelerated variant of the more indolent interstitial pneumonias. |
| Databáze: | OpenAIRE |
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