Fasting Glucose Changes in Adolescents with Polycystic Ovary Syndrome Compared with Obese Controls: A Retrospective Cohort Study
| Autor: | Patricia S. Simmons, Asma Javed, Aida N. Lteif, Alice Y. Chang, Seema Kumar |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
medicine.medical_specialty endocrine system diseases Adolescent Article Body Mass Index Cohort Studies Internal medicine Diabetes mellitus Prevalence Medicine Humans Obesity Retrospective Studies Glucose tolerance test medicine.diagnostic_test business.industry nutritional and metabolic diseases Obstetrics and Gynecology Retrospective cohort study General Medicine Glucose Tolerance Test medicine.disease Impaired fasting glucose Polycystic ovary female genital diseases and pregnancy complications Endocrinology Pediatrics Perinatology and Child Health Cohort Female business Body mass index Cohort study Polycystic Ovary Syndrome |
| Zdroj: | Journal of pediatric and adolescent gynecology. 28(6) |
| ISSN: | 1873-4332 |
| Popis: | To compare changes in fasting glucose among adolescents with polycystic ovary syndrome (PCOS) with those in obese adolescents without PCOS.Retrospective cohort study of 310 adolescents with PCOS and 250 obese adolescents (age range 13 to 18 years) seen at Mayo Clinic, Rochester, MN, from 1996 to 2012.Included for analysis were 98 adolescents with PCOS and 150 obese adolescents who had 2 or more fasting glucose measurements separated by at least 6 months. Adolescents with impaired fasting glucose (IFG) or diabetes were excluded. Multivariate models were used to assess predictors of change in fasting glucose.At diagnosis, adolescents with PCOS had lower body mass index (BMI) (kg/m(2)) and older age than obese adolescents (P.001). Adolescents with PCOS had shorter follow-up (P = .02). Baseline fasting glucose was not different between groups. Mean change in fasting glucose was 2.4 ± 9.4 mg/dL per year for PCOS and 2.2 ± 6.2 mg/dL per year for obese adolescents (P = .83). Significant predictors for change in fasting glucose were BMI and fasting glucose at diagnosis (P.01). Within the PCOS cohort, BMI was a significant predictor for development of IFG (P = .003). Prevalence of hypertension increased in the PCOS cohort from baseline to follow-up (P = .02). PCOS and BMI were significantly associated with development of HTN in the entire cohort.Adolescent girls with PCOS do not show a significant change in fasting glucose or an increased risk for the development of IFG compared with obese adolescents. BMI, not PCOS status, was the strongest predictor for changes in fasting glucose and development of IFG over time. |
| Databáze: | OpenAIRE |
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