Low Serum Oxytocin Concentrations Are Associated with Painful Menstruation
| Autor: | Frank F. Tu, Ellen F. Garrison, Kevin M. Hellman, Lindsey Garfield, Folabomi A. Oladosu, Genevieve E. Roth, Nicole D. Steiner |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Pain tolerance Reproductive medicine Physiology Oxytocin Menstruation 03 medical and health sciences Young Adult 0302 clinical medicine Dysmenorrhea Surveys and Questionnaires Medicine Humans Medical history Pain Measurement 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Clinical trial 030104 developmental biology Pain catastrophizing Female Original Article business Psychosocial hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Reprod Sci |
| ISSN: | 1933-7205 |
| Popis: | Oxytocin-dependent mechanisms are hypothesized to contribute to painful menses, but clinical trials of oxytocin antagonists for dysmenorrhea have had divergent outcomes. In contrast, broader studies have shown that increased systemic oxytocin concentrations are associated with increased pain tolerance and improved psychosocial function. We sought to confirm whether increased serum oxytocin concentrations are associated with menstrual pain and other psychosocial factors. Women with a history of primary dysmenorrhea (n = 19), secondary dysmenorrhea (n = 12), and healthy controls (n = 15) completed pain and psychosocial questionnaires, provided a medical history, and rated their pain during the first 48 h of menses. Serum samples were collected during menses to measure oxytocin concentrations. Oxytocin was significantly lower in participants with a history of primary (704 ± 33 pg/mL; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink