The role of tryptophan degradation in the association between inflammatory markers and depressive symptoms in chronic dialysis patients

Autor: Casper F. M. Franssen, Carl E.H. Siegert, Ido P. Kema, Adriaan Honig, Gertrud L. G. Haverkamp, Friedo W. Dekker, Merel van Diepen, Wim L. Loosman
Přispěvatelé: Internal medicine, Psychiatry, APH - Mental Health, Groningen Kidney Center (GKC), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Lifestyle Medicine (LM)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
CHRONIC KIDNEY-DISEASE
INTERLEUKIN-6
medicine.medical_treatment
Interleukin-1beta
030232 urology & nephrology
HEMODIALYSIS-PATIENTS
ACTIVATION
chemistry.chemical_compound
0302 clinical medicine
Glomerulonephritis
depressive symptoms
QUALITY-OF-LIFE
Prospective Studies
Prospective cohort study
INDOLEAMINE 2
education.field_of_study
biology
Depression
Incidence
Tryptophan
Interleukin
Middle Aged
inflammatory markers
Interleukin-10
C-Reactive Protein
Nephrology
Female
Hemodialysis
Adult
medicine.medical_specialty
Population
tryptophan degradation
03 medical and health sciences
Renal Dialysis
Internal medicine
KYNURENINE
medicine
Humans
Interleukin 6
education
Dialysis
METAANALYSIS
Aged
Transplantation
INTERFERON-GAMMA
business.industry
Tumor Necrosis Factor-alpha
Beck Depression Inventory
3-DIOXYGENASE
chronic dialysis patients
Endocrinology
chemistry
RENAL-DISEASE PATIENTS
biology.protein
business
030217 neurology & neurosurgery
Kynurenine
INDOLEAMINE 2
3-DIOXYGENASE
Biomarkers
Zdroj: Nephrology Dialysis Transplantation, 32(6), 1040-1047
Nephrology Dialysis Transplantation, 32(6), 1040-1047. Oxford University Press
Nephrology, Dialysis, Transplantation, 32(6), 1040-1047. Oxford University Press
Haverkamp, G L, Loosman, W L, Franssen, C F, Kema, I P, Van Diepen, M, Dekker, F W, Honig, A & Siegert, C E 2017, ' The role of tryptophan degradation in the association between inflammatory markers and depressive symptoms in chronic dialysis patients ', Nephrology Dialysis Transplantation, vol. 32, no. 6, pp. 1040-1047 . https://doi.org/10.1093/ndt/gfw212
ISSN: 1460-2385
0931-0509
DOI: 10.1093/ndt/gfw212
Popis: Background: Among chronic dialysis patients, associations have been found between inflammatory markers and depressive symptoms. In this population, no studies have examined the mechanism linking the association between inflammatory markers and depressive symptoms. We examined whether the association between inflammatory markers and depressive symptoms is mediated by tryptophan (TRP) degradation along the kynurenine (KYN) pathway.Methods: The data are part of an observational, prospective cohort study in five urban dialysis centres in The Netherlands. Depressive symptoms were determined with the Beck Depression Inventory. Peripheral blood was collected before dialysis to measure inflammatory markers [high sensitivity C-reactive protein (HsCRP), interleukin (IL)-1 beta, IL-6, IL-10 and tumour necrosis factor-alpha (TNF-alpha)], TRP, KYN and 3-hydroxykynurenine. The KYN/TRP ratio was used as a measure of TRP degradation. The association between inflammatory markers and depressive symptoms was determined using linear regression analysis and adjusted for the KYN/TRP ratio.Results: In total, 490 chronic dialysis patients were included. HsCRP [beta= 3.8; confidence interval (CI): 1.0-6.6], IL-6 (beta= 9.1; CI: 4.0-14.1) and TNF-alpha (beta= 1.3; CI: 0.9-1.7) were associated with the KYN/TRP ratio. We found significant associations between HsCRP (beta= 0.8; CI: 0.3-1.3) and IL-6 (beta= 1.2; CI: 0.3-2.2) levels and depressive symptoms. However, this association was not attenuated after adjustment for the KYN/TRP ratio. Also, no significant associations were found between the KYN/TRP ratio and depressive symptoms.Conclusion: The association between inflammatory markers and depressive symptoms in chronic dialysis patients was not mediated by TRP degradation along the KYN pathway.
Databáze: OpenAIRE
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