Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort
| Autor: | Nick C. Fox, Martin N. Rossor, Dawn Cutler, Chris Frost, F. MacFarlane, Hilary Archer, Tracey Pepple, E. K. Moore, Shona L. Price |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Genotype Apolipoprotein E4 Population Neuropsychological Tests Audiology Alzheimer Disease medicine Humans Memory impairment Dementia Genetic Predisposition to Disease Memory disorder education Psychiatry Geriatric Assessment Aged Psychiatric Status Rating Scales Geriatrics Memory Disorders education.field_of_study Cognitive disorder Neuropsychology Brain Middle Aged Prognosis medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Cross-Sectional Studies Disease Progression Female Geriatrics and Gerontology Alzheimer's disease Cognition Disorders Psychology Follow-Up Studies |
| Zdroj: | International Journal of Geriatric Psychiatry. 21:1206-1212 |
| ISSN: | 1099-1166 0885-6230 |
| Popis: | Background Symptoms of memory loss are a common complaint within the general population and a frequent reason for seeking medical advice. However, the clinical relevance of these symptoms to future development of neurodegenerative disease is uncertain. The aim of this study is to characterise a cohort of individuals with symptoms of memory loss and varying memory impairment, who will be followed longitudinally with serial neuropsychology and neuroimaging to evaluate the clinical relevance of symptoms of memory loss.Method Fifty-eight subjects with symptoms of memory loss were recruited from the National Hospital for Neurology and Neurosurgery. All subjects underwent clinical assessment, APOE4 genotyping, neuroimaging and neuropsychological tests.Results Those with mild cognitive impairment (MCI) had an increased prevalence of the APOE4 allele, impaired performance on tests of memory, measures of IQ and naming compared to controls. Baseline brain volumes were decreased and ventricular size increased. Those with symptoms of memory loss but no cognitive impairment (SNCI) performed significantly worse on tests of memory than the control group.Conclusions The MCI represent a group with multiple risk factors for progression to AD. The SNCI group may represent a heterogeneous group with some individuals in the early stages of AD whilst others' memory complaints are more likely linked to anxiety or personality traits. Copyright (c) 2006 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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