Nonfunctioning endocrine tumors of the pancreas: possibilities of spiral CT characterization
| Autor: | E. Bicego, Luigi Romano, Alessandro Guarise, Giovanni Carbognin, Carlo Procacci, Nicoletta Pagnotta, Carlo Biasiutti, Salvatore Minniti, Simone Accordini, Massimo Falconi |
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| Přispěvatelé: | Procacci, C., Carbognin, G., Accordini, S., Biasiutti, C., Bicego, E., Romano, L., Guarise, A., Minniti, S., Pagnotta, N., Falconi, Massimo |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Adenoma CT pancreas endocrine tumors Sensitivity and Specificity Diagnosis Differential Pancreatic tumor Positive predicative value Humans Medicine Single-Blind Method Radiology Nuclear Medicine and imaging pancreas Aged Retrospective Studies Neuroradiology Aged 80 and over medicine.diagnostic_test business.industry Interventional radiology General Medicine Gold standard (test) Middle Aged Adenoma Islet Cell medicine.disease Pancreatic Neoplasms medicine.anatomical_structure endocrine tumors Female Radiology Differential diagnosis Tomography X-Ray Computed business Pancreas CT |
| Popis: | The aim of this study was to assess the ability of spiral CT to adequately characterize the nonfunctioning endocrine tumors (NFETs) of the pancreas, distinguishing this lesion from the other pancreatic tumors. The spiral CT examinations of 21 cases of histologically proven NFETs, along with those of 29 cases of other pancreatic tumors and tumor-like lesions, were retrospectively reviewed in a blinded fashion by two radiologists, in order to correctly classify the lesions, highlighting the typical signs reported in the literature. Discordant cases were further analyzed in the presence of a third radiologist. The final diagnosis was acquired by means of a majority or overall consensus. The histopathologic examination was considered the gold standard. The sensitivity, specificity, and positive and negative predictive values of CT were calculated. After the consensus evaluation, the correct diagnosis was reached in 72% of cases, with 10% of nonspecific diagnoses of solid pancreatic tumor and 18% of wrong diagnoses. The sensitivity and specificity of spiral CT in identifying NFETs were 66.6 and 82.7%, respectively. The positive and negative predictive values were 73.7 and 77.4%, respectively. In up to 70% of cases the NFET demonstrates a typical aspect of a mass hyperdense in the arterial contrastographic phase eventually associated with hyperdense hepatic metastases in more than half of the patients. This finding does allow the diagnosis of NFET but without certainty indeed, since other tumors can show a similar densitometric behavior and among them particularly the ductal adenocarcinoma. On the other hand, both the solid, hypovascularized NFETs, and the cystic form, cannot be differentiated from the other solid and cystic tumors of the pancreas. |
| Databáze: | OpenAIRE |
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