Histopathological grading and DNA ploidy as prognostic markers in metastatic prostatic cancer
| Autor: | Håvard E. Danielsen, Trond Jørgensen, Kjell J. Tveter, Fredrik Skjørten, Aasmund Berner, K. Yogesan |
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| Rok vydání: | 1995 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Pathology Bone Neoplasms Biology Metastasis Prostate Internal medicine medicine Biomarkers Tumor Humans Orchiectomy Aged Aged 80 and over Observer Variation Ploidies Cancer Prostatic Neoplasms Reproducibility of Results DNA Neoplasm Middle Aged medicine.disease Prognosis medicine.anatomical_structure Evaluation Studies as Topic Image Cytometry Histopathology Ploidy Kappa Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | The present study compares the prognostic potential of tumour grade and DNA ploidy status in patients with advanced-stage prostatic cancer. Two outcome groups were selected on the basis of time to progression and survival after orchiectomy. A poor-outcome group consisted of 32 therapy-resistant patients who experienced disease progression during the first year after orchiectomy and subsequently death due to prostatic cancer during the following year. A good-outcome group consisted of 27 therapy-responsive patients who showed disease regression and no signs of progression during a 3 year follow-up. The primary tumours were graded twice according to WHO and Gleason classification systems by two pathologists. Final agreement between the pathologists was obtained after a consensus meeting. The analysis revealed no prognostic importance of the two histological classification systems (P = 0.62 and P = 0.70) and disclosed weak inter- and intra-observer reproducibility (kappa < 0.70). DNA ploidy analyses were performed by image cytometry on formalin-fixed, paraffin-embedded samples of the primary tumours. Overall, 48% of the tumours were diploid, 20% tetraploid and 32% anueploid. DNA ploidy status did not discriminate between the two outcome groups (P = 0.46). Histological grade and DNA ploidy showed no prognostic importance in patients with prostatic cancer and skeletal metastases. |
| Databáze: | OpenAIRE |
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