Graves' ophthalmopathy: What is the evidence for extraocular muscle specific autoantibodies
| Autor: | N. Fiebelkorn, Aize Kijlstra, R. Vernimmen, R. van der Gaag, M. C. van Dierendonck |
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| Rok vydání: | 1990 |
| Předmět: |
endocrine system
endocrine system diseases Disease medicine.disease_cause Extraocular muscles Autoimmune Diseases Autoimmunity Graves' ophthalmopathy Antigen Antibody Specificity Animals Humans Medicine Autoantibodies Autoimmune disease business.industry Thyroid disease Autoantibody medicine.disease Graves Disease eye diseases Ophthalmology medicine.anatomical_structure Oculomotor Muscles Immunology business |
| Zdroj: | International Ophthalmology. 14:25-30 |
| ISSN: | 1573-2630 0165-5701 |
| DOI: | 10.1007/bf00131165 |
| Popis: | Graves' ophthalmopathy is thought to be an autoimmune disease. Whether this disease is organ specific or one of the manifestations of the closely linked Graves' thyroid disease is still a matter of speculation. Many papers describe autoimmunity to orbital antigens, in particular to extraocular muscles, in patients with Graves' ophthalmopathy. In this paper we have tried to give an overview of the evidence for circulating antibodies against extraocular muscle antigens and to discuss their significance in relation to the immunopathogenesis of the disease. |
| Databáze: | OpenAIRE |
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