Use of Anticancer Platinum Compounds in Combination Therapies and Challenges in Drug Delivery
| Autor: | Ting Wang, Wenliang Li, Weina Zhang, Xiao Xiao, James Trevor Oswald |
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| Rok vydání: | 2018 |
| Předmět: |
Side effect
chemistry.chemical_element Nanotechnology Antineoplastic Agents Platinum Compounds 02 engineering and technology Drug resistance Biochemistry 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Neoplasms Drug Discovery Medicine Humans Platinum Pharmacology Liposome business.industry Organic Chemistry Platinum compounds Safe delivery 021001 nanoscience & nanotechnology Targeted drug delivery chemistry 030220 oncology & carcinogenesis Drug delivery Molecular Medicine 0210 nano-technology business |
| Zdroj: | Current medicinal chemistry. 27(18) |
| ISSN: | 1875-533X |
| Popis: | As one of the leading and most important metal-based drugs, platinum-based pharmaceuticals are widely used in the treatment of solid malignancies. Despite significant side effects and acquired drug resistance have limited their clinical applications, platinum has shown strong inhibitory effects for a wide assortment of tumors. Drug delivery systems using emerging technologies such as liposomes, dendrimers, polymers, nanotubes and other nanocompositions, all show promise for the safe delivery of platinum-based compounds. Due to the specificity of nano-formulations; unwanted side-effects and drug resistance can be largely averted. In addition, combinational therapy has been shown to be an effective way to improve the efficacy of platinum based anti-tumor drugs. This review first introduces drug delivery systems used for platinum and combinational therapeutic delivery. Then we highlight some of the recent advances in the field of drug delivery for combinational therapy; specifically progress in leveraging the cytotoxic nature of platinum-based drugs, the combinational effect of other drugs with platinum, while evaluating the drug targeting, side effect reducing and sitespecific nature of nanotechnology-based delivery platforms. |
| Databáze: | OpenAIRE |
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