Trends in amino acid usage across the class Mollicutes
| Autor: | Héctor Musto, Andrés Iriarte, Leticia Diana, Héctor Romero, Juan Diego Baraibar, Susana Castro-Sowinski |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Genetics biology Genetic Drift Gene Expression General Medicine biology.organism_classification Genetic code Genome Amino acid Negative selection Genetic drift chemistry Bacterial Proteins Structural Biology Phylogenetics Genes Bacterial Mutation Mollicutes Amino Acids Selection Genetic Molecular Biology Gene Phylogeny Tenericutes |
| DOI: | 10.6084/m9.figshare.825489.v2 |
| Popis: | Many studies have explored the mechanisms involved in relative amino acid usage (RAAU) in a variety of prokaryotes and eukaryotes. A strong bias was observed in highly expressed genes (HEGs) of endosymbiotic bacteria. By means of correspondence analysis, we studied the major trends affecting internal variability of RAAU in Mollicutes. The principal trend is related to the usage of smaller, less aromatic, and GC-rich coded amino acids in HEGs. Given the nature of the genetic code, these properties are linked among them. Expectedly, we found a slow evolutionary rate of HEGs, which is likely driven by purifying selection. On the other hand, the rest of the genes accumulate rapid changes as a result of the extreme mutational bias toward A + T of the genomes and genetic drift, increasing internal variability. Amino acid changes across the phylogeny of the group were traced in order to estimate the mean molecular weight and aromaticity trends in each branch. Finally, we compared amino acid usage bias within and between Mollicutes and the free-living Firmicutes. |
| Databáze: | OpenAIRE |
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