Neurophysiological basis of cognitive deficits in long-term survivors of childhood cancer
| Autor: | B D, Moore, D R, Copeland, H, Ried, B, Levy |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Adolescent Lymphoma medicine.medical_treatment Central nervous system Neuropsychological Tests Cognition Arts and Humanities (miscellaneous) medicine Reaction Time Humans Cognitive decline Child Evoked Potentials Cerebral Cortex Leukemia medicine.diagnostic_test Cognitive disorder Neuropsychology Electroencephalography Neuropsychological test medicine.disease Surgery Radiation therapy medicine.anatomical_structure El Niño Female Neurology (clinical) Psychology Cognition Disorders |
| Zdroj: | Archives of neurology. 49(8) |
| ISSN: | 0003-9942 |
| Popis: | • Thirty-three survivors of childhood cancer were tested with event-related potentials (P300), motor reaction time tests, and neuropsychological tests to assess the underlying physiological basis of treatment-related cognitive sequelae. Thirteen patients had received intrathecal chemotherapy, 11 had received intrathecal chemotherapy plus cranial radiotherapy, and nine had been treated without any form of central nervous system therapy. Neuropsychological performance of the groups treated without cranial radiotherapy was normal, but the group given cranial radiotherapy was significantly impaired. Mean reaction time and P300 latency were somewhat slower in the group given intrathecal chemotherapy relative to the group given no central nervous system treatment, but were significantly delayed in the group given cranial radiotherapy. Correlations of reaction time and P300 latency with neuropsychological test scores were also obtained. Results suggest that slowing of cortical activity secondary to white-matter damage may underlie cognitive decline in children treated with intensive central nervous system therapies, especially cranial radiotherapy. |
| Databáze: | OpenAIRE |
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