Visceral abdominal fat measured by computer tomography as a prognostic factor for gynecological malignancies?
| Autor: | Sarah Schott, Benedikt Bau, Tom Buckner, Johanna Nattenmüller, Jalal Arvin, Hans-Ulrich Kauczor, Joachim Rom, Christof Sohn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
obesity Subgroup analysis Computed tomography 03 medical and health sciences BMI 0302 clinical medicine Obstetrics and gynaecology medicine 030212 general & internal medicine Gynecology Univariate analysis body composition medicine.diagnostic_test business.industry Incidence (epidemiology) Cancer Interventional radiology computed tomography medicine.disease Obesity Oncology 030220 oncology & carcinogenesis business gynecological malignancies Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Johanna Nattenmuller 1, * , Joachim Rom 2, * , Tom Buckner 3 , Jalal Arvin 2 , Benedikt Bau 2, 5 , Christof Sohn 2 , Hans-Ulrich Kauczor 1 and Sarah Schott 2, 4 1 Department of Diagnostic and Interventional Radiology, University Hospital, Heidelberg, Germany 2 Department of Obstetrics and Gynecology, University Hospital, Heidelberg, Germany 3 Department of Medical Biometry and Informatics, University Heidelberg, Heidelberg, Germany 4 NCT Heidelberg, DKTK Heidelberg, Heidelberg, Germany 5 Department of Gynecology and Obstetrics, Regional Hospital Nordjylland, Hjorring, Denmark * These authors have contributed equally to this work and defined as co-first author Correspondence to: Johanna Nattenmuller, email: johanna.nattenmueller@med.uni-heidelberg.de Keywords: body composition; BMI; obesity; gynecological malignancies; computed tomography Received: December 19, 2017 Accepted: February 27, 2018 Published: March 27, 2018 ABSTRACT Introduction: Obesity is associated with increased incidence of ovarian (OC), cervical (CC) and endometrium cancer (EC). However, the impact of body composition (BC) on overall survival (OS), especially of visceral adipose tissue (VAT) is not yet understood. Methods: In 189 women with gynecological malignancies (31 OC, 104 CC, 54 EC, mean age 62.9y; mean BMI 26.8 kg/m 2 ; median follow-up 30.7months) with routine staging CT-scans at baseline (mean interval: 4.3 months), densitometric quantification of total (TAT), visceral, and subcutaneous-fat-area (SAT), inter-muscular-fat-area (IMFA), and skeletal-muscle-index (SMI) was performed to analyze the impact of BC on survival. Results: With a mean follow-up of 30.7 months 48 patients had died. We observed no significant differences regarding BMI, the adipose- and muscle-distribution between surviving and deceased women. Univariate analyses revealed no significant BC-parameter with impact on OS, which was confirmed by different multivariate models. A subgroup analysis of OC, CC and EC showed only a protective impact of SMI on survival in the subgroup of CC. Conclusions: Despite the increased incidence of gynecological malignancies in obese, we found no significant impact of BC including VAT on patient survival. Further studies with larger cohorts are needed to quantify BC and its metabolomic impact regarding treatment and prognosis. |
| Databáze: | OpenAIRE |
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