Cognition-Enhancing and Neuroprotective Effects of Hederacolchiside-E from Pulsatilla koreana
| Autor: | Won Rack Choi, Ki-Bong Oh, Chang-Kyun Han |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Administration
Oral Pharmaceutical Science Ranunculaceae Pharmacology Pharmacognosy Plant Roots Analytical Chemistry law.invention chemistry.chemical_compound Cognition Alzheimer Disease law In vivo Cell Line Tumor Drug Discovery Avoidance Learning medicine Animals Humans Amyloid beta-Peptides Dose-Response Relationship Drug biology Traditional medicine Plant Extracts business.industry Organic Chemistry Catechin Saponins biology.organism_classification Rats Neuroprotective Agents Complementary and alternative medicine chemistry Tacrine Toxicity Molecular Medicine Pulsatilla Phytotherapy business medicine.drug Pulsatilla koreana |
| Zdroj: | Planta Medica. 73:665-669 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2007-981530 |
| Popis: | The root extract of Pulsatilla koreana (Ranunculaceae) has been found to have prominent abilities to reverse scopolamine-induced cognitive impairment in rats, and to increase the viability of human neuroblastoma SK-N-SH cells incubated with amyloid-beta peptide (1 - 42) [A beta (1 - 42)]. In vivo and in vitro activity-guided fractionation studies using solvent-partitioning and subsequent chromatographic separations led to the isolation of hederacolchiside-E, an oleanolic glycoside, as an active ingredient. Administration of hederacolchiside-E (30 and 60 mg/kg body weight, P. O.) increased the step-through latency time in the passive avoidance test as efficiently as tacrine (30 mg/kg, P. O.). The neuroprotective effect of hederacolchiside-E on SK-N-SH cells against the toxicity of A beta (1 - 42) was comparable to that of catechin. These data suggest that hederacolchiside-E might be a good therapeutic candidate for the treatment of Alzheimer's disease. |
| Databáze: | OpenAIRE |
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