Sonochemical synthesis of cellulose/hydroxyapatite nanocomposites and their application in protein adsorption

Autor:	Yan-Jun Liu, Ming-Guo Ma, Lian-Hua Fu, Chao Qi, Wen-Tao Cao
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Biocompatibility Simulated body fluid lcsh:Medicine Biocompatible Materials 02 engineering and technology 010402 general chemistry 01 natural sciences Article Apatite Nanocomposites chemistry.chemical_compound Adsorption Microscopy Electron Transmission X-Ray Diffraction Ultrasonics Cellulose lcsh:Science Multidisciplinary Nanocomposite Aqueous solution lcsh:R Proteins 021001 nanoscience & nanotechnology 0104 chemical sciences Durapatite chemistry Chemical engineering visual_art Microscopy Electron Scanning visual_art.visual_art_medium lcsh:Q 0210 nano-technology Protein adsorption
Zdroj:	Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018) Scientific Reports
ISSN:	2045-2322
Popis:	Hydroxyapatite (HA) is the main mineral constituent in the hard tissue of vertebrate, which is recognized as an important biomedical material owing to its excellent bioactivity and biocompatibility. Herein, we report a facile and green sonochemical route for the rapid synthesis of cellulose/HA nanocomposites in NaOH/urea aqueous solution. The in vitro behavior of the cellulose/HA nanocomposites was studied to evaluate the biological response of the nanocomposites following immersion in simulated body fluid for various periods (maximum of 28 days). The HA crystals formed on the surface of the nanocomposites were carbonate-containing apatite, which is similar to the naturally occurring calcium phosphate materials. The HA nanosheets (assembly of nanorods) were mineralized on the surface of the nanocomposites, and maximum mass of the nanocomposites was reached 1.82 times of initial mass after 28 days of soaking. Moreover, the as-prepared cellulose/HA nanocomposites have good cytocompatibility, and show a relatively high protein adsorption ability using hemoglobin as a model protein. These results indicate that the as-prepared cellulose/HA nanocomposites are promising for applications in various biomedical fields such as tissue engineering and protein/drug delivery.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd59c71d9609d667aa9479425257fa7 http://link.springer.com/article/10.1038/s41598-018-25566-7 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.