The clinical implications of mean platelet volume and mean platelet volume/platelet count ratio in locally advanced esophageal squamous cell carcinoma
| Autor: | Yongyan Wang, Shuzhen Sun, Zhao Yn, Jin-Xing Wang, He J, Zhao Bq, Mo Zx |
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| Rok vydání: | 2017 |
| Předmět: |
Male
China medicine.medical_specialty Esophageal Neoplasms Locally advanced 030204 cardiovascular system & hematology Risk Assessment Gastroenterology Esophageal squamous cell carcinoma 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Platelet In patient Platelet activation Mean platelet volume Radical surgery Neoplasm Staging Platelet Count business.industry Healthy subjects General Medicine Middle Aged Prognosis Esophagectomy Case-Control Studies 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Esophageal Squamous Cell Carcinoma business Mean Platelet Volume |
| Zdroj: | Diseases of the Esophagus. 31 |
| ISSN: | 1442-2050 1120-8694 |
| DOI: | 10.1093/dote/dox125 |
| Popis: | As a hallmark of platelet activation, mean platelet volume (MPV) has been identified to be associated with various malignancies. However, the correlation between MPV, mean platelet volume/platelet count ratio (MPR), and esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of this study is to clarify the relevance of MPV and MPR in patients with locally advanced ESCC. Four hundred and fifty-seven cases with newly diagnosed locally advanced ESCC followed by radical surgery and 240 healthy subjects matched for age and gender were included in this study. We retrospectively compared various hematological variables between groups and analyzed the correlation between MPV, MPR, and patients' clinicopathologic characteristics. Preoperative MPV and MPR were found to be significantly decreased in locally advanced ESCC when compared to healthy controls, they were (8.14 ± 1.09 fL vs. 10.23 ± 0.78 fL, P |
| Databáze: | OpenAIRE |
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