Establishment of Stable, Cell-Mediated Immunity that Makes 'Susceptible' Mice Resistant toLeishmania major
| Autor: | Peter A. Bretscher, Juthika N. Menon, Helle Bielefeldt-Ohmann, Guojian Wei |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cellular immunity
T-Lymphocytes Antibodies Protozoan Leishmaniasis Cutaneous Mice Immune system Immunity medicine Animals Leishmania major Immunity Cellular Mice Inbred BALB C Multidisciplinary biology Leishmaniasis biology.organism_classification medicine.disease Virology Immunity Innate Vaccination Immunization Immunoglobulin G Immunology Mice Inbred CBA biology.protein Disease Susceptibility Antibody |
| Zdroj: | Science. 257:539-542 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1636090 |
| Popis: | Cell-mediated, but not antibody-mediated, immune responses protect humans against certain pathogens that produce chronic diseases such as leishmaniasis. Effective vaccination against such pathogens must therefore produce an immunological "imprint" so that stable, cell-mediated immunity is induced in all individuals after natural infection. BALB/c mice "innately susceptible" to Leishmania major produce antibodies after substantial infection. In the present study, "susceptible" mice injected with a small number of parasites mounted a cell-mediated response and acquired resistance to a larger, normally pathogenic, challenge. This vaccination strategy may be applicable in diseases in which protection is dependent on cell-mediated immunity. |
| Databáze: | OpenAIRE |
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