| Autor: |
Ana Abad-Torrent, Pablo Martínez-Vázquez, Jacques Somma, Yung-Wei Hsu, Elisenda Izquierdo |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
British journal of anaesthesia. 129(6) |
| ISSN: |
1471-6771 |
| Popis: |
The Minto remifentanil pharmacokinetic/pharmacodynamic (PK/PD) model is used in target-controlled infusion (TCI) devices. The endpoint used to calculate the PD parameters, including the kWe enrolled 100 patients scheduled for gynaecological surgery. The first group (35 subjects) received an effect site targeted remifentanil infusion (target 1.5 ng mlThe Minto model predicted stable effect-site concentrations within 1.5 min of starting the infusion. Haemodynamic variables stabilised within 5 min, whereas there was a significant increase in pressure pain threshold for up to 15 min in both remifentanil groups. Midazolam had no effect on pressure pain threshold. A PD model based on algometry and Minto PK model was developed.Our results demonstrate the limitation of the Minto PD model at low target remifentanil concentrations, with a discrepancy in the time course between EEG and pressure pain threshold changes. Clinicians should be aware that the time course of onset of analgesic effects is slower than the estimates of the Minto model. Investigators should consider using algometry data in future opioid PD modelling studies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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