Bioavailability and pharmacokinetics of prednisone in humans

Autor:	K.A. Desante, A.R. Disanto
Rok vydání:	1975
Předmět:	Male Chemistry Computers Radioimmunoassay Pharmaceutical Science Half-life Biological Availability Absorption (skin) Pharmacology Bioavailability Peak concentration Kinetics Pharmacokinetics Prednisone medicine Prednisolone Humans Female medicine.drug Half-Life
Zdroj:	Journal of pharmaceutical sciences. 64(1)
ISSN:	0022-3549
Popis:	In a clinical study involving 22 normal adult volunteers, the bioavailability and pharmacokinetics of prednisone tablets with varying dissolution rates were evaluated. Serum levels were measured by a radioimmunoassay for prednisolone. Absorption rate constants and serum half-lives are presented. Substantial serum levels of prednisolone were attained quite rapidly (within 0.5 hr). The observed serum levels were statistically analyzed and fitted to the one-compartment open model with first-order absorption and elimination. A qualitative correlation between the in vitro dissolution rate and the calculated initial absorption rate constants was found. However, the in vitro dissolution rates were not predictive of the overall bioavailability of the prednisone tablets tested in terms of peak concentration and area under the serum concentration-time curve.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cce0d4713e4ed67d99ae25538910bae https://pubmed.ncbi.nlm.nih.gov/1133681 Zobrazit plný text záznamu Plný text