Mannoside-Modified Branched Gold Nanoparticles for Photothermal Therapy to MDA-MB-231 Cells
| Autor: | Tzu-Chien Wu, Han-Chen Lin, Keng-Fang Hsu, Hui-Fen Chen, Chian-Hui Lai, Chiao-Ling Lai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Absorption (pharmacology)
MDA-MB-231 cell photothermal therapy Time Factors Biocompatibility Cell Survival Pharmaceutical Science Metal Nanoparticles Chemistry Techniques Synthetic Photochemistry branched gold nanoparticles Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Mice near-infrared (NIR) laser lcsh:Organic chemistry Cell Line Tumor Drug Discovery Animals Humans Physical and Theoretical Chemistry mannose receptor HEPES Spectrum Analysis Organic Chemistry technology industry and agriculture Temperature Buffer solution Photothermal therapy Xenograft Model Antitumor Assays Disease Models Animal chemistry Microscopy Fluorescence Chemistry (miscellaneous) Covalent bond Colloidal gold Mannosides Cancer cell Molecular Medicine Gold |
| Zdroj: | Molecules Volume 25 Issue 8 Molecules, Vol 25, Iss 1853, p 1853 (2020) |
| ISSN: | 1420-3049 |
| Popis: | Recently, gold nanoparticles (Au NPs) have been used to study the treatment of malignant tumors due to their higher biocompatibility and lesser toxicity. In addition, they can be excited through a specific wavelength to produce oscillating plasmonic photothermal therapy (PPTT) on the basis of the localized surface plasma resonance (LSPR) effect. Au NPs can be heated to kill cancer cells in specific parts of the body in a noninvasive manner. In this study, branched gold nanoparticles (BAu NPs) were prepared by mixing HAuCl4 in a 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) buffer solution in a molar ratio of 1:2000. The UV&ndash vis absorption peak was detected in the range of 700&ndash 1000 nm. Subsequently, BAu NPs were chemically linked to a thiol-modified mannoside molecule via a stable sulfur&ndash Au covalent bond (Man@BAu NPs). Due to the presence of abundant mannose receptors on human-breast-cancer cells, MDA-MB-231, Man@BAu NPs were found to be abundant inside cancer cells. After irradiating the Man@BAu NP-laden MDA-MB231 switch with a near-infrared (NIR) laser at 808 nm wavelength, the photothermal-conversion effect raised the surface temperature of Man@BAu NPs, thus inducing cell death. Our experiment results demonstrated the advantages of applying Man@BAu NPs in inducing cell death in MDA-MB-231. |
| Databáze: | OpenAIRE |
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