Diagnostic value of 169Yb-cis-dichlorodimethionine platinum scintigraphy in patients with malignant lymphomas
| Autor: | Liniecki J, Kukulski K, Brykalski D, Zadrozna O, Kapuściński J |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Lymphoma Organoplatinum Compounds Urinary system Spleen Scintigraphy Sensitivity and Specificity Malignant lymphoma chemistry.chemical_compound medicine Humans Radiology Nuclear Medicine and imaging In patient Ytterbium Aged Pelvic Neoplasms Radioisotopes Kidney medicine.diagnostic_test business.industry Lymphoma Non-Hodgkin General Medicine Meth Middle Aged Thoracic Neoplasms medicine.disease Hodgkin Disease medicine.anatomical_structure chemistry Head and Neck Neoplasms Organ Specificity Abdominal Neoplasms Female business Tomography Emission-Computed |
| Zdroj: | Nuclear medicine communications. 16(9) |
| ISSN: | 0143-3636 |
| Popis: | Ytterbium-169 ( 169 Yb) cis-dichlorodimethionine platinum ( 169 Yb-PtCl 2 Meth 2 ) is a new agent of low toxicity with an affinity for neoplastic tumours. The aim of this study was to assess the diagnostic value of 169 Yb-PtCl 2 Meth 2 scintigraphy in patients with malignant lymphomas. 169 Yb-PtCl 2 Meth 2 scintigraphy was performed in 67 patients with histologically proven malignant lymphoma. Liver, spleen, kidney and bone were among the normal tissues that showed uptake of the radiopharmaceutical. The compound is excreted in the main through the urinary tract. There was no significant activity in the bowels. For evaluation of the images, uptake of activity was scored according to a 5-point scale. In total, 888 sites were evaluated. The sensitivity, specificity and accuracy of lymphoma detection for the body as a whole was 80, 89 and 87%, respectively. The best results were obtained for the head (sensitivity 91%, specificity 89%), neck (sensitivity 84%, specificity 90%) and chest (sensitivity 82%, specificity 84%). In the sub-diaphragmatic region, sensitivity and specificity were 76 and 84%, respectively. Scintigraphy with 169 Yb-PtCl 2 Meth 2 appears to be a sensitive, non-invasive procedure for the staging of malignant lymphomas. The results suggest that it is possible to monitor the therapy of malignant lymphoma by means of 169 Yb-PtCl 2 Meth 2 scanning. |
| Databáze: | OpenAIRE |
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