Increased Expression of Cytoskeletal, Linkage, and Extracellular Proteins in Failing Human Myocardium
| Autor: | Wolfgang Schaper, Bruno Devaux, Yoshi Maeno, Martin Schlepper, Stefan Hein, Annette Heling, Sawa Kostin, Jutta Schaper, Erwin P. Bauer, Wolf-Peter Klövekorn, René Zimmermann |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Cardiomyopathy Vimentin Andrology Internal medicine medicine Humans Cytoskeleton Heart Failure Extracellular Matrix Proteins biology Dilated cardiomyopathy Middle Aged Vinculin medicine.disease Fibronectins Transplantation Fibronectin Cytoskeletal Proteins Endocrinology biology.protein Female Desmin Cardiomyopathies Cardiology and Cardiovascular Medicine |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1524-4571 0009-7330 |
| Popis: | Abstract —Experimental studies have shown that in hypertrophy and heart failure, accumulation of microtubules occurs that impedes sarcomere motion and contributes to decreased ventricular compliance. We tested the hypothesis that these changes are present in the failing human heart and that an entire complex of structural components, including cytoskeletal, linkage, and extracellular proteins, are involved in causing functional deterioration. In explanted human hearts failing because of dilated cardiomyopathy (ejection fraction ≤20%), expression of α- and β-tubulin, desmin, vinculin, fibronectin, and vimentin was determined by Northern and Western blot analysis and compared with normal myocardium from explants not used for transplantation. The mRNA for α- and β-tubulin was increased to 2.4-fold ( P P P P P P P P P P |
| Databáze: | OpenAIRE |
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